/AI12h ago

ESM-C Fails to Distinguish Real Antibodies from Scrambled CDR Sequences

117014475.5K
Original postAnshul Kundaje#1650
Diego del Alamo@DdelAlamo

Despite the huge amount of training data, ESM-C is still unable to distinguish mean-pooled CDRH3 representations of real antibodies from those of antibodies w/ scrambled CDRs. Only VHHBERT seems to do this, and only for natural sequences

3:59 AM · Jun 9, 2026 · 5.5K Views
Sentiment
Sentiment building, check back later.
Cluster Engagement
Posts from X
Most Activity
Most Activity
No ranked X posts are available for this story yet.