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Greg Isenberg Outlines Top Startup Opportunities in AI and Social

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A tweet from 2024 that is still relevant on the biggest startup opportunities right now

6:47 AM · May 16, 2026 View on X

A tweet from 2024 that is still relevant on the biggest startup opportunities right now

1:47 PM · May 16, 2026 · 591 Views

The 36 BIGGEST startup opportunities right now

1. biggest b2c: solving loneliness. third spaces, community apps, IRL

2. biggest b2b: managed AI employees for businesses

3. biggest overlooked: elder tech. 70 million boomers who want products that make them happier & healthier

4. biggest mobile: action apps that do things, not apps you stare at

5. biggest trades: matching platforms for electricians, plumbers, HVAC. supply shrinking

6. biggest consumer social: small social. group chats as products, no feeds, no ai slop

7. biggest ecommerce: agents that recommend products you'll like, shop, buy for you

8. biggest creator: live shows and unscripted content

9. biggest edtech: AI tutors that adapt through conversation

10. biggest SaaS: pay-per-outcome pricing

11. biggest auto: AI service advisor for dealerships. answers the same 15 questions 24/7

12. biggest talent: training non-technical people to operate agents

13. biggest boredom: curated offline experiences delivered to your door. kits, games, challenges. anti-screen products

14. biggest spiritual: the need for belonging is exploding, new formats of spiritual get togethers

15. biggest wellness: longevity biomarkers you actively manage

16. biggest mobile: action apps that do things, not apps you stare at

17. biggest one to solve ai slop: digital verification that you're a real human. every platform will need this within 2 years

18. biggest infrastructure: agent permissions, security, audit trails

19. biggest media: AI native media companies. build distribution, sell products later.

20. biggest parenting: family ops automation. forms, scheduling, logistics

21. biggest accounting: bookkeeping agents that charge per transaction

22. biggest fashion: brand-owned resale. every brand wants to control their secondary market

23.biggest hobbies: adult learning for joy. pottery, woodworking, drawing.

24. biggest skincare: at-home diagnostics. scan, get a protocol, track progress

25. biggest agriculture: precision farming tools for small farms. enterprise version exists, family farm doesn't

26. biggest pest control: subscription pest prevention instead of reactive treatment. the model flip that lawn care already made

27. biggest regulated: on-device AI. healthcare, legal, finance open up when data stays local

28. biggest gaming: AI characters with real memory and relationships

29. biggest dating: agent-mediated matchmaking

30. biggest fitness: adaptive coaching that rewrites your program daily

31. biggest travel: autonomous trip planning and rebooking

32. biggest food: personalized nutrition based on blood work and gut biome

33. biggest pet: health monitoring. $140B industry, almost no tech

34. biggest defense: AI-native security and compliance tools

35. biggest robotics: physical AI. $30 brains on existing hardware

36. biggest nostalgia: products that feel analog. vinyl, paper, handmade. counter-positioning against AI everything

6:13 PM · May 16, 2026 · 66.4K Views
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