Jeff Huber Shares Anthropic Mythos 5.1 Benchmark Claim

Jeff Huber posted that Anthropic shipped Mythos 5.1, which he said leads the ProteinGym benchmark at 49.3% rank correlation against real lab measurements. He also noted a prior publication from two weeks earlier in which Claude achieved a 27% hit rate on autonomous protein binder design campaigns, compared with the 10-15% rate he described as typical. Huber called both results impressive while suggesting they point to further implications. The post includes an attached infographic from Anthropic. No independent confirmation of the claims appears in the packet.