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    AI Reportedly Key to Moderna's Phase 3 Cancer Vaccine

    Posts discuss AI's reported role in selecting mutations for an mRNA therapy by Moderna and Merck.

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    19 Sources, 42d ago, first seen 42d ago

    TLDR

    Polymarket posted that AI reportedly helped design Moderna's personalized skin cancer vaccine after it succeeded in a Phase 3 trial. Other accounts repeated the claim and added that the companies sequence each patient's tumor, compare it to healthy DNA, and use AI to pick mutations most likely to spark an immune response. One reply noted the models are probably small neural networks. Separate posts from founders and investors shared the same headline and expressed excitement about the result.

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    2.6M

    19 Sources, first seen 42d ago

    Combined views

    2.6M

    19 Sources, first seen 42d ago

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    699 comments
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    2.2K reposts

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    699 comments
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    2.2K reposts
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    19 Sources

    @kimmonismusThis is freaking huge: For the first time, a AI-assisted personalized mRNA cancer treatment has succeeded in a Phase 3 trial. Moderna and Merck sequence each patient’s tumor and compare it with their healthy DNA. AI then helps identify which of the tumor’s mutations are most likely to trigger an immune response. From those targets, Moderna produces an individual mRNA treatment encoding up to 34 neoantigens, The earlier Phase 2 trial followed patients with surgically removed high-risk melanoma for five years: - 68.8% remained cancer-free, compared with 49.1% on Keytruda alone - 49% lower risk of recurrence or death - 59% lower risk of distant metastasis or death Now the much larger Phase 3 trial involving 1,137 patients has also succeeded. Absolutely incredible. Dario was right: cancer will be cured in just a few years!
    @venturetwinsYou guys sure you don’t want more data centers?
    @KernaLabsWe started Kerna on the thesis that mRNA would become a widespread therapeutic modality beyond vaccines. Today, Moderna’s mRNA cancer therapy + Keytruda met its Ph3 endpoints. We’re already building the foundation models and in vivo data engine for what comes next.
    @PolymarketJUST IN: AI reportedly played a key role in helping design Moderna's personalized skin cancer vaccine, which succeeded in a Phase 3 trial.
    @ziv_ravidSo this is what happens when you keep telling the model to try again 😍
    @gravicleRT @Polymarket: JUST IN: AI reportedly played a key role in helping design Moderna's personalized skin cancer vaccine, which succeeded in a…
    @timshi_aiRT @KernaLabs: We started Kerna on the thesis that mRNA would become a widespread therapeutic modality beyond vaccines. Today, Moderna’s mR…
    @davefontenot@venturetwins this.
    @chrisalbonCure skin cancer make no mistakes. Believe in yourself.
    @ScobleizerBig day for AI.

    19 Sources

    @kimmonismusThis is freaking huge: For the first time, a AI-assisted personalized mRNA cancer treatment has succeeded in a Phase 3 trial. Moderna and Merck sequence each patient’s tumor and compare it with their healthy DNA. AI then helps identify which of the tumor’s mutations are most likely to trigger an immune response. From those targets, Moderna produces an individual mRNA treatment encoding up to 34 neoantigens, The earlier Phase 2 trial followed patients with surgically removed high-risk melanoma for five years: - 68.8% remained cancer-free, compared with 49.1% on Keytruda alone - 49% lower risk of recurrence or death - 59% lower risk of distant metastasis or death Now the much larger Phase 3 trial involving 1,137 patients has also succeeded. Absolutely incredible. Dario was right: cancer will be cured in just a few years!
    @venturetwinsYou guys sure you don’t want more data centers?
    @KernaLabsWe started Kerna on the thesis that mRNA would become a widespread therapeutic modality beyond vaccines. Today, Moderna’s mRNA cancer therapy + Keytruda met its Ph3 endpoints. We’re already building the foundation models and in vivo data engine for what comes next.
    @PolymarketJUST IN: AI reportedly played a key role in helping design Moderna's personalized skin cancer vaccine, which succeeded in a Phase 3 trial.
    @ziv_ravidSo this is what happens when you keep telling the model to try again 😍
    @gravicleRT @Polymarket: JUST IN: AI reportedly played a key role in helping design Moderna's personalized skin cancer vaccine, which succeeded in a…
    @timshi_aiRT @KernaLabs: We started Kerna on the thesis that mRNA would become a widespread therapeutic modality beyond vaccines. Today, Moderna’s mR…
    @davefontenot@venturetwins this.
    @chrisalbonCure skin cancer make no mistakes. Believe in yourself.
    @ScobleizerBig day for AI.