/AI2h ago

AI Analysis of CT Scans Flags Up to 30-Fold Cardiac Death Risk

3411177.8K
#717Eric Topol
Original post
Eric Topol@EricTopol#717inAI

The study cited in the article that I considered a wake-up call found a 13-fold risk of cardiac mortality with 1 inflamed artery, which rose to nearly 30-fold when all 3 arteries were inflamed, as determined by AI of non-invasive CT angio imaging https://www.thelancet.com/article/S0140-6736(24)00596-8/fulltext

Eric Topol@EricTopol

The next frontier for prevention of heart and vascular disease isn't targeting lipids. It's about blocking inflammation. These are some of the ongoing clinical trials @NatureMedicine https://www.nature.com/articles/d41591-026-00030-6

7:06 AM · Jun 6, 2026 · 2K Views
Sentiment

Users approve of parallels drawn in discussions of AI CT imaging showing inflamed arteries raising cardiac death risk up to 30-fold.

Pos
100.0%
Neg
0.0%
1 comments with sentiment.
Cluster Engagement
Posts from X
Most Activity
Most Activity
VIEWS5.7KBOOKMARKS5LIKES19RETWEETS3REPLIES1
Eric Topol@EricTopol

And that markedly elevated risk of inflammation was similar with no significant narrowing/blockage known as obstructive coronary artery disease (CAD)

Eric Topol@EricTopol

The study cited in the article that I considered a wake-up call found a 13-fold risk of cardiac mortality with 1 inflamed artery, which rose to nearly 30-fold when all 3 arteries were inflamed, as determined by AI of non-invasive CT angio imaging https://www.thelancet.com/article/S0140-6736(24)00596-8/fulltext

2hViews 5.7KLikes 19Bookmarks 5
Eric Topol@EricTopol

If you find this big shift interesting, it's reviewed in a Ground Truths post, which are all open-access, free https://erictopol.substack.com/p/the-big-shift-in-cardiology-to-atheroma

2hViews 2.5KLikes 6Bookmarks 2
Esteban F-Hinojosa@EFdezHinojosa

I recall that with the evolution of our understanding of sepsis and ARDS, we moved from focusing solely on the visible lesion to recognizing that the host’s inflammatory response is as consequential as the initial insult. A similar conceptual shift appears to be emerging in coronary artery disease

2hViews 10Likes 1
Eric Topol@EricTopol

@EFdezHinojosa Yes, great parallel. Thanks.

2hViews 6Likes 1