biosingularity.wordpress.com — Howard Hughes Medical Institute researchers have discovered a molecular link between a high-fat, Western-style diet, and the onset of type 2 diabetes. In studies in mice, the scientists showed that a high-fat diet disrupts insulin production, resulting in the classic signs of type 2 diabetes.
Dec 29, 2005 View in Crawl 4
dilbertDec 30, 2005
Interesting article, I didn't know GLUT2 (Glucose transporter II) was important. In most studies they only look at GLUT1 (basal glucose transporter) and GLUT4 (inducible glucose transporter).High insulin is not good for the body. But when you take a low-carb diet (so with high fat) your insulin production is reduced. I think that a high-carb high-fat diet (like pizzas hamburgers and French fries) is the culprit and it seems to me that the Montignac diet makes ever more sense.BTW, a high-fat diet makes you feel full sooner so your taking up less calories and lose weight, which is beneficial in fighting NIDDM (Type II diabetes). Beware with trans-fatty acids (hydrogenated fat) as they are one of the causes of atherosclerosis.
bentcornerDec 30, 2005
Howard Hughes Medical Institute? I didn't know he was a doctor. I thought he was this creepy guy that built a big wooden airplane, walked only on pillows, and grew his finger nails a foot long.
mangabladeDec 30, 2005
lets agree: WHEN YOU EAT BAD FOOD, BAD THINGS HAPPEN, DONT EAD BAD FOOD.
dhughesDec 30, 2005
Another interesting thing I heard about diabetes was related to fingerprints. People who develop diabetes (I assume Type I i.e. genetic cause) have fingerprints that are different, a fetus' organs (most notably the pancreas) and fingerprints both develop at the same time. If there is a problem both are affected. Weird but cool.
suppermanDec 30, 2005
Argh, stupid spammer...Pretty interesting paper. However, there are still holes to be filled. Very importantly, whether human patients have problems with GnT-4a? Has there been any genetic evidence for this enzyme in familial cases? How does the 'high fat diet' affect the enzyme?Normally, I don't like correlation studies that have no evidences for a causal link. But, since diet is a well accept risk factor for diabetes, it makes this study worth pursuing.
fragalotDec 30, 2005
Like no s**t?
frduffyDec 30, 2005
I too have lived a Low carb Hi fat diet for 2 years next week. My Triglycerides, bad colesterol and blood pressure have never been better. I was diagnosed with type 2 diabetes a few years before and i watched my blood sugar slowly rising over time and the addition of more and more medication. Within the first month of my new diet my blood sugar was down over 70 points. With my doctors consent I cut most of my medications and my blood sugar remains almost normal. All that and I eat what even I think is a HUGE amount of fat. As Duke said, the mechanisms involved here need serious study and are far far from simple.
Closed AccountMay 13, 2008
How many years did that take..geez<a class="user" href="http://diabetes-diabetic1.org/">http://diabetes-diabetic1.org/</a>
dmcmJan 14, 2009
Find more information about Type 2 Diabetes and diet on the links at the Diabetes Library page at <a class="user" href="http://diabetes.boomja.com/Type-2-Diabetes-28.html.">http://diabetes.boomja.com/Type-2-Diabetes-28.html ...</a>