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- CrankMyBlueSax, on 05/11/2009, -1/+34My white blood cells do not crawl, they saunter.
- radicaldementia, on 05/11/2009, -1/+27Actually that is somewhat true. There are actually many more bacterial cells in your body than human cells (though human cells are much larger). We are essentially a giant ecosystem for all kinds of interesting lifeforms. The vast majority of them are either ignored or are beneficial (like the bacteria in your gut the helps digest food). It's the rare invasive species that sets off the immune system.
Anyway, this is a pretty interesting article. Macrophages are a key component of the adaptive immune system and are like Pacman cells, they phagocytose (eat) any dead cells or foreign material. It is essential that macrophages be able to properly detect what is actually supposed to be eaten and what is just part of the body, so this new discovery gives a lot of insight to how they do this. - MrInfallible, on 05/11/2009, -0/+14Also your immune systems needs practise, if you lived all your life inside a sterile room and came to a big city you would probally get very sick. There was a recent study done that showed dirty children had better immune systems than those with obsessivly clean parents.
- Arsenard, on 05/11/2009, -2/+15I have often wondered if we were actually a symbiotic composite of viruses, microbes, parasites, etc that control our 'health' for their benefit!!
- TomboAhi, on 05/11/2009, -0/+12Also crawling inside you? Lemmywinks.
- failtrain, on 05/11/2009, -1/+13Mine float around lifeless.
I have aids. - Kuestionmark, on 05/11/2009, -0/+10hop on the magic school bus
- Brassbud, on 05/11/2009, -1/+11I'm sure glad I got rid of mine; that's disgusting.
- keyforce, on 05/11/2009, -1/+10Mine swagger.
- inactive, on 05/11/2009, -1/+9Mine does the stanky leg.
- hawkspur, on 05/11/2009, -0/+7The body is amazing. There are even several different sub-types of white blood cells that do different things, like a "command" cell that directs other white blood cells. Soldier cells that ingest bacteria and produce laser-designator like antibodies. Different soldier cells attack different types of organism, cells that kill human cells that are giving off the kill signal, garbage cleaning cells. etc.
Overall, the body's cells are much more interesting if you make military analogs of them. - asgardshill, on 05/11/2009, -0/+7The very thought of Raquel Welch in a skin-tight wetsuit swimming along my circulatory system gives me a ... special feeling.
- RiMac, on 05/11/2009, -2/+9Mine roll.
- bdogm, on 05/11/2009, -0/+6These wounds they will not heal
- Brassbud, on 05/11/2009, -0/+5Facing the wall and hitting the spacebar?
- Lefts, on 05/11/2009, -1/+6You'd think.
But if you're in the business, you'd find that things are harder than they seem. - gropo, on 05/11/2009, -0/+5Lymphocytes are my favorites... Kind of the ninja assassins of the body, slipping in to the blood stream from their native lymph ducts, abducting them back in to the lymphatic system and disposing of the corpses.
- bnut, on 05/12/2009, -0/+5I really don't understand what they supposedly discovered. This process is called "rolling" and is taught in the immunology class I took this spring at university. The so called legs are called cell-adhesion molecules that bind to their receptor sites along the blood vessel wall as they move along the vessels by the natural flow of blood. Blood vessel walls near a site of inflammation release information transmitters called cytokines which the WBCs can pick up which will upregulate other cell adhesion molecules to stop the WBC in its tracks and migrate through the blood vessel toward the site of inflammation.
- Coinspinner, on 05/12/2009, -0/+5They were teaching this in all major non-Christian Universities 20 years ago. Trust me.
- pegothejerk, on 05/11/2009, -0/+4It gives the mental image of an RPG like doom inside my body. crawling around, finding secret passages, destroying foreign matter and invaders. I'm a kickass game inside!
- GhostInAShell, on 05/12/2009, -0/+4Yeah, I thought this was realllll old news.
Selectins bind mucins, allows for rolling along vessels in direction of chemokine gradient
in response to vascular addressins at damaged/chemokine-producing tissue, ICAMS and integrins bind together, allowing for arrest and extravasion.
Lalala - seandfeeney, on 05/11/2009, -0/+4Take a look at http://www.ted.com/index.php/talks/bonnie_bassler_ ... kind of explains your theory
- seandfeeney, on 05/11/2009, -0/+4It is articles like this that amaze me on how little we actually know about life around us.
- dsmx, on 05/11/2009, -0/+4It also provides a new path to a possible cure to a lot of diseases
- TomboAhi, on 05/12/2009, -0/+3I believe that is the original, much more disturbing version of "I Know an Old Lady Who Swallowed a Fly"
- Namco, on 05/12/2009, -2/+5Thank you Lt. Data. That will be all. I'll be in my ready room sipping on a cup of *****' Earl Grey.
- phishneslo, on 05/12/2009, -0/+3I majored in chemistry and philosophy in my undergrad... But I can just tell that you two know what you are talking about (the benefits of a liberal arts school, I guess...)
- mmittimm, on 05/11/2009, -3/+5Wow, this seems like something we should have already discovered.
- jaxter2010, on 06/17/2009, -0/+2Effin' Awesome!
- lisaawesome, on 05/11/2009, -0/+2If Lemmiwinks the gerbil is already up there I suggest sending in Lemiwinks my cat to take care of it.
- widoka, on 05/11/2009, -1/+3wounds
- laterthandawn, on 05/11/2009, -0/+2God, why hast thou forsaken me with such squeamishness?
- jonnyfatman, on 05/11/2009, -0/+2So youtube knew all along? What else does it know?
- TheInimitable, on 05/11/2009, -0/+2It's both fascinating and disturbing at the same time! Hm...
- inactive, on 05/12/2009, -1/+3Mine do the hustle.
- 408train, on 05/12/2009, -0/+2the crawling makes sense, as thats probably how they detect bad guys too. great mental picture
- Coinspinner, on 05/12/2009, -0/+2I'm a bio major from MSU, graduated 16 years ago, and yes, they were teaching this then.
I imagine some facet of the movement was discovered, not that they move in general.
and PS gropo, who the ***** would digg you down for saying that ?! I returned ya to 1 :) - skidork, on 05/11/2009, -1/+2The bad thing about these cells is they tend to aggregate in blood vessels on certain problem spots, and this causes plaque buildup.
- Arachnivore, on 05/11/2009, -0/+1I thought this was old news. There's even a 3 or 4-year old animation of lukecytes crawling along a blood vessel.
http://www.youtube.com/watch?v=BVvvx5HGpLg - Arachnivore, on 05/11/2009, -0/+1There's a TED talk about that animation:
http://www.ted.com/index.php/talks/david_bolinsky_ ...
David Bolinsky describes what is actually going on in the animation. - Nature1, on 05/11/2009, -1/+2Way to make me feel weird about a normal body function...
- Altotus, on 05/12/2009, -0/+1For what it's worth, the observation that leukocytes crawl was first published in 1979. In subsequent years, the mechanisms of cytoskeletal rearrangement, adhesion, and taxis have been worked out. When I was studying biophysics (1992-ish), this was a popular model case for assembly/disassembly of intracellular structures.
- 408train, on 05/12/2009, -0/+1the good thing is they protect our body from most infections.
- Urrelles, on 05/12/2009, -0/+1How is this new research. This past decade of us filming and picturing White Blood cells in action, and we never came to the conclusion that they crawl. I saw pics and videos of thse little buggers in aciton 10 years ago when I was in high school.
- charlietuna, on 05/12/2009, -0/+1Yep,
http://www.youtube.com/watch?v=0AZKyEX6XXg - gropo, on 05/11/2009, -1/+2Yeah, I learned this as a fact in Anatomy/Physiology a year ago...
- CCPH, on 05/12/2009, -0/+1I think the key difference is in this sentence in the article "Before this study, scientists thought the legs only appeared after the cells left blood vessels. "
And a small correction, I believe the "legs" mentioned are really the pseudopodia previously thought to extend during transmigration, not this early in leukocyte extravasation. The adhesion molecules are likely to be on the pseudopodia.
I do need to find this article in the library and read the primary source for myself. - Coinspinner, on 05/12/2009, -0/+1yeah, they quite literally crawl around your lungs.
Weird eh? - mizarone, on 05/12/2009, -1/+1Mine rick roll.
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