What is Digg?33 Comments
- elijahyossie, on 11/02/2009, -0/+18Pancreatic cancer is horrible - painful, and a killer.
- perryc, on 11/02/2009, -0/+16It's still a mystery how with all the technology and advancements we haven't been able to detect the treatment for any kind of cancer til now...
- Janinco, on 11/02/2009, -0/+9Successful treatment for cancer can't come soon enough...!
Thanks for posting this informative article. - wcsoccerfan, on 11/02/2009, -0/+8Pancreatic cancer is not as simple as this article makes it sound. I work in a lab at Purdue that works with a protein called Mist1, a DNA binding transcription factor. Mist1 is sort of the opposite of pdx1. Mist1 expression in the pancreas causes the pancreas to retain normal function, at least in mouse models. When its turned off and Kras is turned on in the pancreas, it typically ends poorly for the mice.
The problem is that there is no one solution like this article leaves you to believe. Whether Kras is being overexpressed, pdx1 is being improperly expressed, or Mist1 turns off, or any other of dozens of problems are taking place, its always something different.
Sorry to be the bubble burster, but this is only a hair on the head of the beast that is cancer. Just keep telling the government to fund science programs!! - vertinox, on 11/02/2009, -0/+8Yeah. My Grandad died of pancreatic cancer. I'd hate to go like that.... Pretty much spent the last several weeks in hospice on morphine.
- supersonicjim, on 11/02/2009, -0/+6All these articles on this topic aren't good for my hypochondria.
- asgardshill, on 11/02/2009, -0/+6I lost my father to this disease - his last two weeks on Earth were a living hell for him. And I'm certainly inclined to donate more of my disposable cash to research into eradicating it than other causes.
- thepierre, on 11/02/2009, -0/+4My mom died of this in 2005. It was very sad to see her go from being such a strong woman, to not even being able to lift her own head. Very sad, but this article should be passed on so people may see that progress is being made.
- searcade, on 11/02/2009, -0/+4my grandma died from this, i was a little kid and don't remember much but from what my mum and everyone experienced from this i wish there was a cure
- sabach, on 11/02/2009, -0/+4I've lost 3 friends to pancreatic cancer. Glad to see they're making progress.
- Idiggapony, on 11/02/2009, -0/+3The most common cause of chronic pancreatitis is chronic alcohol use, which causes more than two thirds of cases. Gallstones also cause some cases. In many cases, no particular cause can be found.
- freezo1994, on 11/02/2009, -1/+4Dear Digg,
when you find an ACTUAL cure for cancer, call me.
24.245.14.201,
digg user - emjaymj, on 11/02/2009, -0/+3It's a killer mostly because for the most part it's NOT that painful. Symptoms don't usually present until the cancer is already very advanced, and the late diagnoses are why pancreatic cancer patients typically have such a poor prognosis.
- xav8r, on 11/03/2009, -0/+2Dugg for showing that things are never as simple as they seem!
- Antialias, on 11/03/2009, -0/+2Well I guess I should have checked the source better. I I just clicked his link and went straight to the chart listing alkaline/acidic foods. I certainly don't believe any of the miracle diet/pills to cure disease BS.
- elijahyossie, on 11/03/2009, -0/+2In the end stages, it's very painful indeed. My father in law died of it, aged 51.
- rusty0101, on 11/03/2009, -0/+1I have to admit that I did not get the impression that they considered the situation to be simply the pdx1 situation. They were able to show that pdx1 has an effect regarding one variety of pancreatic cancer, but that there are at least two distinct varieties involved. Of course I may have misread the article, and I don't have access to the raw data.
- bubbachuck, on 11/03/2009, -0/+1a general rule for cancerous cells is that more the more division and more inflammation/injury a cell experiences, the more likely it will be cancerous. hence cells that rapidly turnover such as cells in the colon are more likely to be cancerous whereas cells that divide slowly/not at all such as muscle cells rarely become cancerous. hence, noxious chemicals in the lungs leads to lung cancer, alcohol leads to stomach/liver cancer. these are absolute rules, but are good to keep in mind.
the finding in question "They also found that tumors can form in other, more mature pancreatic cell types, but only when they are injured or inflamed, suggesting that pancreatic cancer can arise from different types of cells depending on the circumstances" is not at all a surprising result. i would say it's obvious. more inflammation = more cancer. always. - Antialias, on 11/02/2009, -0/+1Why would acidity cause cancer? I guess I should stop drinking orange juice.
- brettmjohnson, on 11/02/2009, -0/+1"However, mature pancreatic cells, such as insulin-secreting cells, became cancerous only when they expressed K-ras and also suffered from chronic inflammation."
Anyone have an idea what could lead to "chronic inflammation"? Diet? substance abuse? viral or bacteriological infection? obesity? food additive? - Idiggapony, on 11/02/2009, -0/+1There's a small group of *****-spewing con artists who have infomercials on TV at 3 AM, in which they hawk useless products that are supposed to make your body more acidic, or more alkaline, or something, in order to prevent cancer and stop aging and cure depression and give you more energy and improve your sexual performance. Sometimes these people or their victims create web sites like the one above.
Please don't waste your time with this garbage. - Antialias, on 11/02/2009, -0/+1Good to know. I would never have guessed.
- EddiePotato, on 11/02/2009, -1/+2Citrus actually has an alkalizing effect on the body:
http://www.justgoodenergy.com/2009/08/03/acidalkal ... - rollin03, on 11/02/2009, -1/+1How about analyzing the fluid that bathes these cells? Maybe they'd find that acidity causes cancer. That'd be too obvious and unscientific though.
- karikature, on 11/03/2009, -0/+0In addition to above, high levels of triglycerides can cause pancreatitis.
- acheron22, on 11/03/2009, -1/+1There's always the Ketogenic Diet: http://www.time.com/time/health/article/0,8599,166 ...
What causes inflammation in the pancreas? Increased blood sugar.
What raises blood sugar? Carbs, all of them are identical to sugar after digestion.
If you eat enough of a high carb diet the beta cells in the islet of lagerans (sp?) burn out causing Type II diabetes. The cancer incidence rate is significantly higher for diabetics for all cancers especially pancreatic.
Moreover most cancers do not use the standard mitochondrial pathway and ferment the excess glucose to produce energy. Lower the glucose available and many of them will die. (See the Warburg Effect) - digglet08, on 11/02/2009, -0/+0You know what IS?
- ToxicG, on 11/02/2009, -2/+1There's some promising studies showing medical dose amounts of Curcumin supplements can destroy certain types of cancer (pancreatic included). Studies done by legit medical personnel. Full story below. Check out the link: http://www.endonurse.com/hotnews/curcumin-kills-ca ...
Curcumin Kills Cancer Cells Quickly
10/30/2009
CORK, Ireland—Researchers from the University College Cork and Mercy University Hospital, Cork, reported curcumin started killing cancer cells within 24 hours of administration in laboratory tests. They investigated the phytochemical commonly found in the curry spice turmeric and its effects on esophageal cancer, which they said is increasingly prevalent and has poor survival rates.
Curcumin’s effect on cancer cells was not due only to inducing apoptosis (programmed cell death), and cancer cells in two of the cell lines studied began to digest themselves, according to researchers. Lead author Sharon McKenna noted in killing cancer cells, curcumin used a system of messages that was unexpected. Under the “expected” process of apoptosis, certain protease enzymes (caspases) that trigger cell death. However, researchers added to the curcumin-treated cells a compound that would stop the enzyme-triggered cell death, they saw no difference in the number of cells curcumin killed.
In their British Journal of Cancer article the scientists concluded curcumin represents “a promising anticancer agent for prevention and treatment of esophageal cancer.” - RizzosBack, on 11/02/2009, -1/+0The pancreas, maybe?
- aadautech, on 11/03/2009, -2/+0Chemotherapy uses drugs to destroy cancer cells by stopping them from growing or multiplying. Treatment may consist of just one drug or a combination of drugs. It may be given by mouth or by injection into a muscle or vein. The drugs enter the bloodstream and travel through the body, making chemotherapy a good choice for cancer that has spread. It is also useful after surgery to kill any cancer cells left behind.
http://blog.aadautech.com/post/Pancreatic-cancer-a ... - digglet08, on 11/02/2009, -3/+0.........................
wut - KevinRowz, on 11/02/2009, -5/+1I would wager a wild guess that pancreatic cancer originates in the pancreas?
- anexanhume, on 11/02/2009, -8/+1FTA:
"They also found that tumors can form in other, more mature pancreatic cell types, but only when they are injured or inflamed, "
BUTT SECKS.
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