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89 Comments
- DrewPeacock, on 12/02/2008, -1/+23QUICK, CRIMINALIZE IT!
- WriterSD, on 12/02/2008, -0/+15If that works, does it mean that just taking melatonin would basically do the same thing?
- inactive, on 12/02/2008, -0/+13Dude.... you can buy melatonin in a bottle, over-the-counter, for dirt cheap at your local drug or health food store. Why pay for some pharmaceutical brand of melatonin?
- Rally603, on 12/02/2008, -0/+10Sometimes, when I want to go to sleep, I lay down and shut my eyes. And for other times when I don't want to go to sleep, I don't do that.
- inactive, on 12/02/2008, -0/+8The only side effects of melatonin are that some people report having very vivid dreams. Other than that... nothing. But even more than this, melatonin has other benefits. It reduces blood pressure at rest and it boosts your immune system. Your body's natural melatonin levels decrease with age, this is one of the primary reasons why older people have a harder time sleeping.
- linagee, on 12/02/2008, -0/+73 grams of melatonin is enough to put out a horse. Perhaps you meant mg?
- archer104, on 12/02/2008, -0/+7@bsl4doc
What do you mean it does nothing? Are you saying the old melatonin supplement is worthless? It sure as hell makes me tired about an hour after taking. I know that it works I just want to know if I am screwing up my body. - inactive, on 12/02/2008, -0/+7Go buy melatonin!... it's dirt cheap and it is everywhere. Melatonin has been available on the market for decades.
- hwood, on 12/02/2008, -2/+8I'll bet the side effects are worse than the cure.
- archer104, on 12/02/2008, -0/+6Melatonin is used for jet lag. I have been taking melatonin as a sleep aid because I can't shut off my mind when I go to bed. From what I've seen there aren't any serious side effects. Anyone know of any?
- inactive, on 12/02/2008, -3/+8I worked in circadian biology at Vanderbilt for two years. Taking melatonin does absolutely nothing for the human body as far as circadian rhythms. If the body senses excess melatonin, you just pee it right out. This drug works by tricking the inner clock (superchiasmatic nucleus) into releasing more melatonin naturally, thus the receptors won't "spit it back out", so to say, like they do when you just take supplements.
- Neiby, on 12/02/2008, -0/+5***** drug companies. We already have melatonin. Why not use it? Because they say the "results are mixed." That's just their way of saying, "We're going to come up with a patentable drug that does the same thing, but you should pay for our drug instead of buying melatonin at the store."
*****. - inactive, on 12/02/2008, -0/+5I don't care for jet lag. Then again, I just either drink coffee or sleep. My sleep cycles don't get messed up. Period.
- VaporBro, on 12/02/2008, -2/+7Marijuana. No side effects. *****. Awesome.
- leontes, on 12/02/2008, -0/+5I use an EDGE tablet. I'll upgrade to 3G after the next iPhone refresh in July.
- louisut, on 12/02/2008, -0/+5"Because melatonin can't be patented, drug companies have been interested in developing melatonin mimics, such as tasimelteon, which can be patented."
It's not about you, it's about the $$$. For me, half a 3g tablet works great when I need help resetting my clock after late weekends. - DigSomeMore, on 12/02/2008, -4/+8This would be pretty useful if proven to work...
- Ellipsys, on 12/02/2008, -2/+6@bsl4doc Even the MayoClinic (who are pretty "traditional") disagrees with you.
http://www.mayoclinic.com/health/melatonin/NS_pati ...
An A rating indicates strong scientific evidence, and there are plenty of conditions that need more study. Can't call this one all in someone's head. - divinediva, on 12/02/2008, -5/+9This is a very promising step.
- rwac, on 12/02/2008, -1/+5If I use the instant release melatonin, I get up in 3 hrs or so, and can't go back to sleep.
I have to use the sustained release stuff to sleep all night.
It's not the placebo effect, for sure. - linagee, on 12/02/2008, -0/+4Yes. Don't take too much. Read the melatonin wiki for more info. Don't take more than 3mg or so a day. Even 1mg per day works wonders.
- flamewall203, on 12/03/2008, -0/+4Why do Americans feel the need to have drugs for everything? Is there something I don't understand?
- j3ff86, on 12/02/2008, -0/+4I always take Comanaprosil when going on a plane. May cause dizziness, sexual nightmares, and sleep crime.
- Fatcheeseguy, on 12/02/2008, -0/+3I just want to know what are some of my fellow digger's solutions to jet lag.
I've heard like staying up all night through the flight might help. - archer104, on 12/02/2008, -0/+3No, like I said earlier I expected it not to work. And I tried other things that were supposed to work but didn't (no placebo effect there).
- Akairenn, on 12/02/2008, -0/+3Can they do something about my being unable to walk after a four hour flight, due to my legs being locked with pain? My god, I swear those seats are designed for midgets.
- inactive, on 12/02/2008, -0/+3Makes me a bit more groggy in the morning, but just in a nice sleepy kind of way, not hung over or anything. Really great stuff.
- Lucas123, on 12/02/2008, -0/+3Just make little fists with your feet in the carpet.
- Maxjan, on 12/02/2008, -0/+3I don't think you can patent/copyright anything made by a living human. Which is why this drug may be more successful in being advertised, since they can make money on it
- onlines, on 12/02/2008, -0/+3I thought sleep has been around for eons. I hope it gets re-approved.
- jakebathman, on 12/02/2008, -0/+3http://downforeveryoneorjustme.com/latimes.com/
- TheMachine1, on 12/02/2008, -0/+3http://www.chemblink.com/products/609799-22-6.htm
Found the drugs structure.
http://www.vandapharma.com/development-vec162.html
Company sight. - inactive, on 12/02/2008, -1/+4I worked in circadian biology at Vanderbilt for two years. Taking melatonin does absolutely nothing for the human body as far as circadian rhythms. If the body senses excess melatonin, you just pee it right out. This drug works by tricking the inner clock (superchiasmatic nucleus) into releasing more melatonin naturally, thus the receptors won't "spit it back out", so to say, like they do when you just take supplements.
- czarr, on 12/02/2008, -0/+3The side affect is having a harder time falling asleep when not taking it from regular use.
- dvdt101, on 12/02/2008, -0/+3@DWalla
Thank you. I have been using melatonin to eliminate jet lag during long oversees trips for years. Works great and there are no side effects. - adamdigg, on 12/03/2008, -0/+3And their patentable drug will most likely cause some horrible side effect that shows up after 10 years.
- inactive, on 12/02/2008, -1/+4"Look up "psychosomatic" and "placebo effect"."
Is the buzz you get from a cup of coffee also placebo effect? - linagee, on 12/02/2008, -0/+3It's melatonin supplement in a bottle. They've had this for decades at any drugstore.
- JCEEZ, on 12/03/2008, -0/+3its called redbull during the day, then alcohol at night...works like a charm. I travel to Asia all the time... nothing is better.
- thebza451, on 12/03/2008, -1/+3cocaine's a hell of a drug
- lornali, on 12/03/2008, -0/+2Allow the lag to catch up. Do NOT make it run
- elliotys, on 12/02/2008, -0/+2No it doesn't.
- Maxjan, on 12/02/2008, -1/+3Trust me,
Don't overdose on this stu-
zZzZzZz - inactive, on 12/02/2008, -1/+3..
- jwk4heels, on 12/03/2008, -0/+2Read: Final exam week in college.
- octover, on 12/03/2008, -1/+3Melatonin works great for me, my father-in-law is a doctor and stocks up each time he goes to the US (can't get it here in Sweden). It works great for jet lag. I find it less useful for a sleep aid when not fighting jet lag though.
- zydeco, on 12/02/2008, -0/+2Get on your destination's time right away. Don't sleep when you land and get to your hotel. Take a short nap after lunch (set an alarm), then stay up as late as possible that night.
(This is mostly for going east. Going west is a cinch, unless you cross the date line) - archer104, on 12/02/2008, -1/+3It works. I know this from personal experience over a three month period. I just need to find out if it is harmful.
- DrewPeacock, on 12/03/2008, -0/+2You haven't thought this through. Or maybe you're just dumb.
Or maybe I'm being close-minded. You could easily be both. - elliotys, on 12/04/2008, -0/+2Heroine is an mu-opioid receptor agonist, that mimics the bodies natural endorphins. Opioid receptors are found in the central and peripheral nervous system, (so pretty much all over the body). And while heroine may make you drowsy, it does nothing to reset your bodies natural circadian rhythm, and most people, when taking opioids, do notice a hungover/foggy feeling the next day.
Melatonin, and melatonin analogs, on the otherhand, do not activate opioid receptors. They will actually bind to melatonin MT1 and MT2 receptors, which causes a completely different physiological response, ie. affects your bodies "sleep system" rather than opioids which affect your bodies "pain system". -
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