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whowillsurvive2012.com - The Mayan Calendar predicts the end of time: 2012. See the trailer for 2012, opening November 13.
151 Comments
- Rawpulse, on 01/30/2008, -0/+71http://www.youtube.com/watch?v=RO8MP3wMvqg&e
- inactive, on 01/30/2008, -0/+46That's terrifyingly fascinating.
- geekchic, on 01/30/2008, -13/+58I was half expecting a porn video where condoms are not used.
- Kronos6948, on 01/30/2008, -4/+39Did I just watch HIV teabag a healthy T cell?
- Erik1, on 01/30/2008, -4/+31Pfft, who DOESN'T know this?
- SHuisman, on 01/30/2008, -5/+27"here is a very interesting video that, although in a simple way, explains it all."
Interesting CHECK
Simple NO
explains it all NO - Amadeus2490, on 01/30/2008, -2/+23Each T-Cell has thousands of CCR5 receptors. . .think of them as a bunch of USB ports, for lack of better phrasing, that the virus plugs into. It converts the cell into an anerobic one, which means it uses your blood sugar for fuel instead of oxygen, and this feeds the virus. The cell doesn't last very long when it's running primarily on glucose, so it dies. The virus exits, swims through your blood or lymphatic fluid and repeats the process infinitely.
Scientists are working on a way of inhibiting the CCR5 gene in order to prevent the virus from entering your T-cells; which would effectively give you immunity to the virus and even allow your body to clear itself of the infection. - looke, on 01/30/2008, -0/+17So basically with no treatment you are royally screwed
- icepick314, on 01/30/2008, -8/+22needs to be animated by Japanese studio and feature transforming mechas piloted by teenage girls..
- Uruviel, on 01/30/2008, -2/+15This was textbook high-school material in my Biology course. Great to live in a country where education does not suck.
- int19h, on 01/30/2008, -0/+12Great explanation! More computer-analogies to biology, please! :)
- GiggleStick, on 01/30/2008, -1/+12A country with verbs, perhaps?
- Scynet, on 01/30/2008, -0/+9They dont know anything, they are forced to do it by the laws of physics and chemistry like a ball is forced to fall on the ground by gravity. They're also constructed by something else that was forced to construct them. At this level, consciousness doesn't exist, obviously. All you saw was tools. Yeah, you see the DNA floating right into the right place in the video without anything affecting it, that's not how it works in reality.
- catachip, on 01/30/2008, -0/+9For those confused about the weird names in the beginning, it's not that hard. The virus wants to invade a cell, but, it can just go up and attack it. It has to dock with the cell first, like two spaceships docking in space. When the virus approaches the cell, its GP120 protein binds to and docks the CD4 on the target cell. This is like an initial soft dock. This binding causes a change in the shape of the cells co-receptors CCR5 and CXCR4 receptors that allows them to bind the compliment co-receptors on the virus. This results in the hard dock, and the virus can now proceed to fuse its membrane and take over the cells machinery to replicate itself. HIV is a very, very smart virus.
- Smoozle, on 01/30/2008, -1/+9Don't tempt the "this is Sparta" crowd.
- mumugugu, on 01/30/2008, -4/+11OK, your loving god created the HIV virus. We get it.
- Number23, on 01/30/2008, -0/+7Please tell me you don't vote.
- Scynet, on 01/30/2008, -0/+6Of course it didn't form from random particles, a HIV virus is very complicated and likely evolved from some slightly less complicated virus, which in turn was something less complicated a million years ago and so on. Time is on life's side.
- inactive, on 01/30/2008, -3/+9Oh no, not this ***** again.
Just because something looks complicated doesn't mean it has to have been designed. If you really understood evolution through natural selection, you'd know that. Seemingly intelligent, complex systems are built up from slightly simpler systems, which are built in turn from even simpler systems - that is the process of evolution.
Unless you can make a good case for "irreducible complexity" of molecular biology (which, might I add, no one ever has) it doesn't seem "reasonable" to dismiss evolution based on a gut feeling.
Of course, if you're simply calling the evolutionary process intelligent, it might be true, depending on how you look at it. - oldsk00l, on 01/30/2008, -0/+5I couldn't agree more, society is full of asshats.
- GiggleStick, on 01/30/2008, -0/+5Actually, Trojans will help prevent this problem.
Thank You, Tip your waitresses. - has2k1, on 01/30/2008, -2/+7It looks like an evil spaceship landing on a planet.
- Pahtcub, on 01/30/2008, -3/+8I'M IN YUR BLUDZ EATN ALL UR T CELLZ
- blast_flame, on 01/30/2008, -3/+8Evolution can create quite complex structures.
http://youtube.com/watch?v=mcAq9bmCeR0
http://youtube.com/watch?v=SUvLR2yyWuE - Loyaleagle, on 01/30/2008, -0/+5I'm currently taking a class on HIV/AIDS and this is pretty much what we're learning about. Great visual!
- blast_flame, on 01/30/2008, -1/+6Evolution can create quite complex structures.
http://youtube.com/watch?v=mcAq9bmCeR0
http://youtube.com/watch?v=SUvLR2yyWuE - RungeKutta, on 01/30/2008, -0/+5While that's one of my favorite Pink Floyd songs, I'm not quite sure what that has to do with HIV infection.
- RungeKutta, on 01/30/2008, -1/+5I think it's funny how a number of comments quote a section of the video and then follow up with, "what??". That's pretty much your average person's response to anything semi-technical about computer architecture/operation/etc, and I guess the same thing applies here too.
- inactive, on 01/30/2008, -0/+4So then, you're speaking about abiogenesis. Not evolution. You are correct that there needs to be a reproducing population. However, I'm not sure what you mean by "system of heredity", and why does variation have to be "safe"? (Humans die of genetic defects all the time.) And, why is DNA/RNA at all a prerequisite for evolution? Sure, it allows for efficient evolution, but I believe that proponents of abiogenesis suggest that DNA itself could have slowly evolved from progressively simpler systems - so natural selection *could* have happened before DNA. In current cells, sure, cells are complicated, but singular cell organisms spent 100s of millions of years evolving before anything larger came along.
It boils down to irreducible complexity again, which as I said, no one has ever given a good case for. I suggest *you* go to a library and read more on theories of abiogenesis. They've done experiments to simulate the "primordial soup", and the theories are not as far-fetched as you think. - inactive, on 01/30/2008, -2/+6I actually understood that - I need a drink ... or 6.
- catachip, on 01/30/2008, -1/+5This video is made by a pharmaceutical company called Boehringer-Ingelheim. These types of videos are shown to MDs and scientists at conferences. They have two other excellent videos. One on the development of HIV resistance, it explains why HIV will eventually nearly all of those infected with it due to treatment failure ( http://www.youtube.com/watch?v=TvNOmwRh0I0 ) and the other describes the current class of HIV drugs and their new one called Tipranovir, which is a non-nucleoside reverse transcriptase inhibitor ( http://www.youtube.com/watch?v=VoMGqPqnyDQ ). Both use fantastic animation to illustrate this. Of course, remember they are trying to sell their drug at the same time.
- christoast, on 09/04/2008, -1/+5hacks
- tyywebb, on 01/30/2008, -0/+4Meh, I always thought that was a funny idea. People don't really like calling viruses life because they are so alien to the idea of an organism which is what most people think of when they think of life. But basically viruses are just a more elegant less complex version of everything we call life.
- catachip, on 01/30/2008, -1/+5That's like saying there are "well-known scientists who think differently about evolution". The mechanism of HIV infection and the progression to immune failure is the the theory accepted by nearly all scientists, and in particular those actually in the HIV field.
- xdvx, on 01/30/2008, -8/+12it works like trojan. But how the ***** it developed so great infection mechanism? HIV works like programmed, hard to believed it was developed from random chemical reactions.
- tyywebb, on 01/30/2008, -0/+4Pool's closed due to AIDS?
- int19h, on 01/30/2008, -0/+4Word of the day: selfboggled
- geekchic, on 01/30/2008, -0/+3If mankind is skilled enough to create such an incredibly complex virus in a lab - how is it that those same mega-genuises cannot cure it (or any other illness for that matter)?
- theodenking, on 01/30/2008, -0/+3Although it's debatable whether viruses are technically life.
- bbschaefer, on 01/30/2008, -0/+3I guess the server contracted full-blown AIDS and died.
- koick, on 01/30/2008, -0/+3Yeah, just imagine the patience it takes to figure these things out!
- solid12345, on 01/30/2008, -0/+3So I take it HIV was created in 3D Studio Max R2?
- geekchic, on 01/30/2008, -2/+5They are better known for being cranks though.
- geekchic, on 01/30/2008, -0/+3I am sure that if you get your credit card out and pay for the hosting excess, then the website will reappear.
- catachip, on 01/30/2008, -0/+3http://www.youtube.com/watch?v=RO8MP3wMvqg&e
- MyExSucks, on 01/30/2008, -1/+4*****, I learned this my freshman year of high school, here in the wonderful United States of America
- geekchic, on 01/30/2008, -0/+3They no more "know" how to carry out their actions than a nut "knows" how to fit onto a screw.
- KRa104, on 01/30/2008, -0/+3As a side note, there's a certain percentage of humans that lack the CCR5 receptor and cannot be infected by the HIV virus.
- Gromdul, on 01/30/2008, -0/+2GP120 is a shorter name for glycoprotein. The 120 is simply a number assigned to it to distinguish it from other proteins in the HIV. The number assigned isn't arbitrary. But I'm not sure exactly where it comes from. Probably related to how many carbons it has or something...
Cells have protein receptors. This is how one cell can communicate with others. HIV hijacks CD4 for its own purposes. - bmc1919, on 01/30/2008, -1/+3that's like keeping an open mind about how the earth might be flat
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