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- Zetsubou, on 05/09/2009, -3/+52Top 10 with 12 pages.
Dysentery
Many of you young whippersnappers might not have been around to play Oregon Trail, the educational title that brought gaming to classrooms across America in 1971 (and recently re-introduced to iPhone/iPod Touch), but trust us: It was a harrowing experience. Your virtual settlers could fall prey to any number of ailments, attacks and pitfalls, but perhaps the worst was dysentery, the digestive disease that was, it seemed, inevitable on that long journey west. Sure, it won't turn you into a zombie, but anyone who experienced this game knew the icy chill that came with receiving word that one of your settlers had succumbed to it.
Orochi's Plague
Never has widespread blight looked this stylish. The eight-headed demon Orochi unleashes a sickness upon ancient Nippon in the gorgeous PS2 game Okami, sapping the countryside of its life and forcing a confrontation with Amaterasu, goddess of the sun. Orochi's plague manifests itself through the blackening of all that is green and beautiful in the land, and seeing it replaced with grass, flowers and other natural wonders when you save different sections of the game world is motivation enough to spur you on in Amaterasu's quest.
Forced Evolutionary Virus
Finding mutated freaks in a post-nuclear war wasteland shouldn't be all that surprising, but the Fallout series threw a twist into things by bringing viral elements into play. The Forced Evolutionary Virus was first created as a means of protecting soldiers against a possible Chinese bio-attack, but in the hands of the horribly mutated Master, ended up being the catalyst for the creation of the highly evolved (yet grotesque and sterile) super mutants. It was later adapted into a lethal pathogen that almost killed everyone on the west coast by the Enclave. Bottom line: If you see a vat of green goo, stay away.
Creeping Derangea
Most diseases kill you in some horrible way - you know, blood from the eyes, body parts falling off and liquefied internal organs. Not so in Creeping Derangea, an IDS-created bio-weapon in the post-apocalyptic strategy game Advance Wars: Days of Ruin. Initially only capable of infecting those under the age of 20, Creeping Derangea causes flowers to grow inside the body and break out of the skin. It's excruciatingly painful but, hey, at least no one will need to send bouquets to your funeral.
Chimera Virus
In terms of worldwide impact, the Chimera Virus is a mother of a disease, more or less reshaping the mid-20th century globe in Resistance: Fall of Man. First appearing after the Tunguska event (a mysterious explosion in Siberia thought to be due to a meteor strike)m the virus was spread throughout Europe by the invading Chimera, turning humans into horribly mutated monsters who could then be turned on their former kind. Of course, you MIGHT luck out like Nathan Hale and end up with superhuman abilities thanks to a Chimera Virus infection, but given how long the odds are of that happening (and Nathan Hale's eventual fate), it's best avoided, altogether.
Venom Symbiote
It's bad enough when the alien symbiote-infected Eddie Brock is running around causing havoc, but Spider-Man: Web of Shadows gives us a New York City overrun by extraterrestrial black goo that turns civilians into zombie-like creatures and super-beings into nastier, fanged versions of themselves. Whatever you thought of the game, seeing a virtual Manhattan overrun with Venom-spawn was one of Web of Shadows' coolest conceits, and made every save of a citizen about to be infected feel like a colossal victory for your friendly neighborhood web-slinger.
Porphyric Hemophilia
Por-what with the who, now? This nasty bug is Oblivion's version of vampirism, and anyone who's spent any significant time in Cyrodiil has likely run afoul of it at least once. Unlike other diseases on this list, vampirism in Oblivion actually isn't all that bad, conveying certain stat and ability bonuses. Of course, you also take damage from the sun, need to feed on other humans and may be attacked by town guards on sight depending on how deeply the infection has its fangs in you.
FoxDie
As befits the Metal Gear Solid mythology from which it spawned, the FoxDie virus has a long and convoluted history. It was designed as a biological weapon, capable of targeting a specific individual's DNA and inducing cardiac arrest. Due to variations in Solid Snake's physiology, however, it mutated and became capable of killing at random and possibly wiping out humanity as we know it. Then, it got changed back, which canceled out the original mutation. It's all very confusing, but the bottom line is that FoxDie is not a virus to be messed with.
Corrupted Blood
Was it a glitch? Or was it a fascinating study of the way real-word epidemics can spread? The jury's still out on World of Warcraft's Corrupted Blood debuff, which originated in the Zul'Grub instance and spread through several of the game's servers, killing lower-level characters by the dozens and infecting countless others. It was a major annoyance for some players, but others went out of their way to spread the disease - ah, griefers. At any rate, Blizzard was eventually forced to reset all the game's servers to kill the Corrupted Blood bug. If only swine flu could have been wiped out that easily.
T-Virus
Perhaps the most well-known disease in the world of gaming, Umbrella Corporation's "Tyrant" virus has been creating mutagenic zombies for over 13 years. First appearing in the original Resident Evil, the T-Virus was manufactured as a means of producing the perfect biological weapon, but went on to lay necro-waste to the citizens of Raccoon City, the Arklay Mountains region and certain uncharted islands. Despite various interventions by S.T.A.R.S., nukings and other measures, it continues to raise a ruckus, and as long as the RE franchise continues to be some of the best survival horror around, odds are it won't be squelched any time soon. -- Adam Swiderski - WoWii, on 05/09/2009, -0/+11Dugg for T Virus
Buried for 12 ***** pages, are you ***** me? - Xaevier, on 05/09/2009, -0/+10Surprised they didn't use the Undead plague from WC3/WoW, that is a good deal more significant than the blood plague.
- SniperZero, on 05/09/2009, -1/+11"If only swine flu could have been wiped out that easily."
rm -rf /var/cache/swineflu
shutdown -r now
*will only work if you have updated to matrix v9.05 - peters1023, on 05/09/2009, -0/+10I for one thank you.
- Neiby, on 05/09/2009, -0/+6Damn. Just seeing that thumbnail from Oregon Trail put me back in 7th grade immediately.
- vsujohn2, on 05/09/2009, -0/+6Omg! The deadly Gamedaily virus!
- therusher, on 05/09/2009, -0/+5*****. Dysentery.
On a related note, anyone else just keep playing the hunting minigame in the (semi)updated version, even if you didn't need food? - Emused, on 05/09/2009, -0/+4"All your virii are belong to us"
- stellarspellar, on 05/09/2009, -0/+4No mention of Deus Ex?
- CyberStriker, on 05/10/2009, -0/+3It's a good thing none of those viruses will EVER get Madagascar!
- quaunaut, on 05/10/2009, -0/+3The Undead Plague didn't bring WoW itself to a screeching halt. When NO ONE could enter the cities without dying, you're kinda just in a bad place.
- ELCad, on 05/08/2009, -0/+3No Fuzz Bomb?
- EvanGH, on 05/09/2009, -0/+2Didn't GamesRadar already do this article?
http://www.gamesradar.com/f/gamings-most-memorable ...
And, y'know, not cut into pieces over 12 pages to increase viewcounts? GameDaily hurts my mind. - zephc, on 05/09/2009, -0/+2they had corrupted blood, but the (planned) Scourge outbreak last fall before WoW:WotLK was great, and a ton of fun.
- Evilblobs, on 05/09/2009, -0/+2What an incredible stretch of the term pandemic they've done in selecting some of those.
- Alias1431, on 05/09/2009, -0/+2I can't wait for Swine Flu Adventure Land.
- BingoPower, on 05/10/2009, -0/+2I was thinking the very same thing. What's next?
Top 10 Games where you turn left more than right.
Top 10 Games where the protaganist's girlfriend actually prefers another member of his family.
Oh well. - DouglasQ, on 05/10/2009, -0/+2These internet gaming lists really are starting to run out of ideas.
- Neiby, on 05/10/2009, -0/+2Very cool! I think that's a newer version than the I played. I think the one I had was even more old school than that! lol
- Philbert, on 05/10/2009, -0/+2Two words. Parasite Eve
- Philbert, on 05/10/2009, -0/+1Ready to go back again?
http://www.virtualapple.org/oregontraildisk.html - slayerbabe, on 05/10/2009, -0/+1At least the Umbrella corp did have a vaccine for the T-virus
- Demalaxy, on 05/10/2009, -0/+1Grey Death from Deus Ex? No?
- dadaas, on 05/10/2009, -0/+1T-Virus is great!!!
- DarkMagic349, on 05/09/2009, -0/+1Was I the only one that on seeing the Fallout Master picture, read the words in all of it's different voices?
- Nistelrooy, on 05/10/2009, -0/+1Dugg for WoW's corrupted blood. I personally killed tons and tons at the org auction house.
- BingoPower, on 05/10/2009, -0/+1Dugg for correct use of "Virii".
- downer06, on 05/10/2009, -0/+1I wish I had been playing wow when the corrupted blood was around.
- EMGroup, on 05/14/2009, -0/+1Maybe we will see the swim flu in action in RE6.
- SteveMax, on 05/10/2009, -0/+1What, you want a list of Nascar/Indy games?
- Nateon, on 05/13/2009, -0/+1I hated the vampirism disease in Oblivion. Such a pain in the ass to get rid of.
- sndream, on 05/10/2009, -0/+1What type of virus caused the author to put 10 virus across 12 pages.
- ELCad, on 05/08/2009, -0/+1From the game Agent USA.
- kevro, on 05/10/2009, -1/+1http://www.virtualapple.org/oregontraildisk.html
- dalibero, on 05/12/2009, -0/+0Awesome. I miss Oregon Trail
- Jeras, on 05/10/2009, -1/+0Unfortunately, they left out Team Fortress Classic's medic ability to infect enemies players. Then those players could infect their teammates just by merely touching them! Now that is bio-terrorism of pandemic portions in a game at its best.
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